Journal Publications

In Progress

* denotes UA students

Nelli Mnatsakanyan, Han-A Park, Jing Wu, Xiang He, Marc Llaguno, Maria Latta, Paige Miranda, Besnik Murtishi, Morven Graham, Richard J Levy, Evgeny V Pavlov, and Elizabeth A. Jonas. ATP synthase F1 subcomplex is the gate of the c-subunit pore of the mitochondrial permeability transition.

Submitted to Cell Reports (Oct 21, 2020)

Han-A Park, Madison Scott*, Allison Stumpf*, and Kimberly H. Lackey. Lycopene Promotes Neurite Development by Improving Energy in Primary Hippocampal Neurons.

Submitted to Nutrition Research (July 31, 2020)

 

Han-A Park, Allison Stumpf*, Katheryn Broman*, Joseph Jansen*, Tracie Dunn*, and Kristi M. Crowe-White. Dual Function of Lycopene In Mitochondrial Regulation of Hydrogen Peroxide-Challenged Primary Cortical Neurons.

Submitted to Frontiers in Nutrition (July 17, 2020)

Published

 

* denotes UA students

20. Pawel Licznerski, Han-A Park, Harshvardhan Rolyan, Rongmin Chen, Nelli Mnatsakanyan, Paige Miranda, Morven Graham, Jing Wu, Nicole Cruz-Reyes, Nikita Mehta, Sana Sohail, Jorge Salcedo, Erin Song, Charles Effman, Samuel Effman, Lucas Brandao, Nancy Xu, Amber Braker, Valentin K. Gribkoff, Richard J. Levy and Elizabeth Ann Jonas. ATP synthase c-subunit leak causes aberrant cellular metabolism in Fragile X syndrome. Cell (2020) Aug 4;. doi: 10.1016/j.cell.2020.07.008. PMID: 32795412.

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19. Han-A Park, Katheryn Broman*, and Elizabeth A. Jonas. Oxidative Stress Battles Neuronal Bcl-xL in a Fight to the Death. Neuronal Regeneration Research (2021) Jan;16(1):12-15. doi: 10.4103/1673-5374.286946, PMID: 32788441, Review

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18. Han-A Park, Mary Margaret Hayden*, Sydni Bannerman*, Joseph Jansen*, and Kristi M. Crowe-White, Anti-Apoptotic Effects of Carotenoids in Neurodegeneration. Molecules (2020) Jul 29;25(15):E3453. doi: 10.3390/molecules25153453. PMID: 32751250, Review

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17. Han-A Park, Spenser R. Brown*, and Yonghyun Kim. Cellular Mechanisms of Circulating Tumor Cells during Breast Cancer Metastasis.

International Journal of Molecular Sciences (2020) Jul 17;21(14):E5040. doi: 10.3390/ijms21145040. PMID: 32708855, Review

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16. Han-A Park and Amy C. Ellis,  Dietary Antioxidants and Parkinson's Disease.  Antioxidants (2020) Jul 1;9(7):E570. doi:10.3390/antiox9070570. PMID: 32630250, Review

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15. Han-A Park, Nelli Mnatsakanyan, Katheryn Broman*, Abigail U. Davis*, Jordan May*, Pawel Licznerski, Kristi M. Crowe-White, Kimberly H. Lackey, and Elizabeth A. Jonas.  Alpha-Tocotrienol Prevents Oxidative Stress-Mediated Post-Translational Cleavage of Bcl-xL in Primary Hippocampal Neurons. International Journal of Molecular Sciences (2019) 21(1), 220. doi: org/10.3390/ijms21010220. PMID: 31905614.

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14. Rongmin Chen, Han-A Park, Nelli Mnatsakanyan, Yulong Niu, Pawel Licznerski, Jing Wu, Paige Miranda, Morven Graham, Jack Tang, Anita Boon, Giovanni Cossu, Wim Mandemakers, Vincenzo Bonifati, Peter Smith, Kambiz Alavian,  Vincenzo Bonifati, and Elizabeth A. Jonas. Parkinson’s Disease protein DJ-1 regulates ATP synthase protein components to increase neuronal process outgrowth. Cell Death & Disease, (2019) 13;10(6):469. doi: 10.1038/s41419-019-1679-x. PMID: 31197129.

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13. Han-A Park, Katheryn Broman*, Allison Stumpf*, Sara Kazyak*, and Elizabeth A. Jonas. Nutritional Regulators of Bcl-xL in the Brain. Molecules, (2018) 19;23(11). pii: E3019. doi: 10.3390/molecules23113019. PMID: 30463183, Review

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12. Han-A Park and Elizabeth A. Jonas. ΔN-Bcl-xL, a therapeutic target for neuroprotection. Neural Regeneration Research, (2017) 12(11):1791-1794. doi: 10.4103/1673-5374.219033. PMID: 29239317, Review

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11. Han-A Park, Pawel Licznerski, Nelli Mnatsakanyan, Yulong Niu, Silvio Sacchetti, Jing Wu, Brian M. Polster, Kambiz N. Alavian, and Elizabeth A. Jonas.  Inhibition of Bcl-xL prevents pro-death actions of ΔN-Bcl-xL at the mitochondrial inner membrane during glutamate excitotoxicity. Cell Death & Differentiation, (2017) 24(11):1963-1974. doi: 10.1038/cdd.2017.123. PMID: 28777375.

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10. Han-A Park, Pawel Licznerski, Kambiz N. Alavian, Marya Shanabrough, and Elizabeth A. Jonas. Bcl-xL is necessary for neurite outgrowth in hippocampal neurons. Antioxidants & Redox Signaling, (2015) 10;22(2):93-108. doi: 10.1089/ars.2013.5570. PMID: 24787232.

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9. Hongmei Li, Han-A Park, and Elizabeth A. Jonas. Measurement of synaptic activity using fluorescent synaptopHluorin in isolated hippocampal neurons. Bio-Protocol, (2014)  5;4(23). pii: e1304. PMID: 27446978.

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8. Han-A Park and Elizabeth A. Jonas. Mitochondrial membrane protein Bcl-xL, a regulator of adult neuronal growth and synaptic plasticity: multiple functions beyond apoptosis. Neural Regeneration Research, (2014) 1;9(19):1706-7. doi: 10.4103/1673-5374.143413. PMID: 25422630, Review

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7. Kambiz N. Alavian, Gisela Beutner, Emma Lazrove, Silvio Sacchetti, Han-A Park, Pawel Licznerski, Hongmei Li, Panah Nabili, Kathryn Hockensmith, Morven Graham, George A. Porter, and Elizabeth A. Jonas. An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore. PNAS,  (2014) 22;111(29):10580-5. doi: 10.1073/pnas.1401591111. PMID: 24979777.

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6. Elizabeth A. Jonas, Silvio Sacchetti, Han-A Park, Emma Lazrove, Gisela Beutner, George A. Porter, and Kambiz A. Alavian. The c-subunit of the ATP synthase forms the pore of the PTP. Biophysical Journal, 106, 3a-4a (2014)

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5. Han-A Park, Natalia Kubicki, Surya Gnyawali, Yuk Cheung Chen, Sashwati Roy, Savita Khanna, and Chandan K. Sen. Natural vitamin E α-tocotrienol protects against ischemic stroke by induction of multidrug resistance-associated protein 1. Stroke, (2011) 42(8):2308-14. doi: 10.1161/STROKEAHA.110.608547. PMID: 21719775.

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4. Gayle Gordillo, Huiquing Fang, Han-A Park, and Sashwati Roy. Nox-4-dependent nuclear H2O2 drives DNA oxidation resulting in 8-OHdG as urinary biomarker and hemangioendothelioma formation.  Antioxidants & Redox Signaling, (2010) 15;12(8):933-43. doi: 10.1089/ars.2009.2917. PMID: 19817625.

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3. Han-A Park, Savita Khanna, Cameron Rink, Surya Gnyawali, Sashwati Roy, and Chandan K. Sen. Glutathione disulfide induces neural cell death via a 12-lipoxygenase pathway. Cell Death & Differentiation, (2009) 16(8):1167-79. doi: 10.1038/cdd.2009.37. PMID: 19373248.

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2. Savita Khanna, Han-A Park, Chandan K. Sen, Trimurtulu Golakoti, Krishanu Sengupta, Somepalli Venkateswarlu, and Sashwati Roy.  Neuroprotective and antiinflammatory properties of a novel demethylated curcuminoid. Antioxidants & Redox Signaling, (2009) 11(3):449-68. doi: 10.1089/ARS.2008.2230. PMID: 18724833.

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1. Savita Khanna, Sashwati Roy, Han-A Park, and Chandan K. Sen. Regulation of c-Src activity in glutamate-induced neurodegeneration. Journal of Biological Chemistry, (2007) 10;282(32):23482-90. doi: 10.1074/jbc.M611269200. PMID: 17569670.

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Book Chapters

4. Katheryn Broman*, Abigail U. Davis*, Jordan May*, and Han-A Park.  Lifestyle factors, Mitochondrial Dynamics, and Neuroprotection in Neuroprotection - New Approaches and Prospects. London, UK, Intech. (2019)

Link   Down

3. Han-A Park, and Elizabeth A. Jonas. Mitochondrial Regulators of Synaptic Plasticity in the Ischemic Brain in Synaptic Plasticity. London, UK, Intech. p39-67 (2017)

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2. Elizabeth A. Jonas, George A. Porter, Gisela Beutner, Nelli Mnatsakanyan, Han-A Park, Nikita Mehta, Rongmin Chen, Kambiz A. Alavian. The mitochondrial permeability transition pore: molecular structure and function in health and disease in Molecular Basis for Mitochondrial Signaling. New York City, NY, Springer Publishing. p69-105 (2017)

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1. Han-A Park, Sashwati Roy, Savita Khanna, and Chandan K. Sen. Current Technologies in Single Cell Microinjection and Application to Study Signal Transduction in Method in Redox Signaling. Larchmont, NY,  Mary Ann Liebert, Inc. p71-77 (2010)

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Presentations

* denotes UA students; _denotes presenters.

31. Tracie Dunn*, Spenser Brown*, Nelli Mnatsakanyan, Elizabeth A. Jonas, Yonghyun Kim, and Han-A Park. Cellular Mechanisms of Metabolic Remodeling during Fluid Sheer Stress-induced Metastasis. Nutrition 2020, on-line (Jun 2020)

​ePoster

 

30. Tracie Dunn*, Spenser Brown*, Nelli Mnatsakanyan, Elizabeth A. Jonas, Yonghyun Kim, and Han-A Park. Is the c-subunit of F1Fo ATP Synthase an Important Target in Circulating Cancer Cells? Undergraduate Research & Creative Activity Conference, on-line, (April 2020)

29. Tracie Dunn*, Spenser Brown*, Nelli Mnatsakanyan, Elizabeth A. Jonas, Yonghyun Kim, and Han-A Park. Alteration of energy metabolism in circulating cancer cells. Alabama Dietetic Association, Montgomery, AL (Feb 28, 2020)

28. Nelli Mnatsakanyan, Han-A Park, Jing Wu, Marc C Llaguno, Besnik Murtishi, Maria Latta, Ellie Davis, Paige Miranda, Youshan Yang, Fred Sigworth, Elizabeth A Jonas.  Mitochondrial Megachannel Resides in Monomeric ATP Synthase. Annual Meeting of the Biophysical Society, San Diego, CA (Feb, 2019)

 

27. Han-A Park Roles of Bcl-xL in mitochondrial function and neuronal survival. Department of Biology Seminar, University of Alabama, Tuscaloosa, AL (Nov  8, 2019)

26. Pawel Licznerski, Han-A Park, Paige Miranda, Rongmin Chen, Morven Graham, Nelli Mnatsakanyan, Jing Wu, N. Cruz-Reyes, N. Mehta, S. Sohail, J. Salcedo,  Valentin Gribkoff, Besnik Murtishi, Harshvardhan Rolyan, Richard Levy, and Elizabeth A. Jonas. Mitochondrial inefficiency linked to abnormal metabolism, synaptic immaturity and behavioral deficits in fragile X syndrome. Neuroscience, Chicago, IL (Oct, 2019)

25. Nelli Mnatsakanyan, Han-A Park, Jing Wu, Marc C Llaguno, Besnik Murtishi, Paige Miranda, Fred Sigworth, Elizabeth A Jonas. Excitotoxic neuronal death inducing megachannel resides in monomeric F1FOATP synthase. Neuroscience, Chicago, IL (Oct, 2019)

24. Harshvardhan Rolyan, Paige Miranda, Han-A Park, Silvio Sacchetti, Kambiz Alavian,  Nelli Mnatsakanyan, Pawel Licznerski, H. Imamura, H. Noji, J. Shepherd, A. Chavez, Suzanne Zukin, and Elizabeth A Jonas. Mitochondria dependent metabolic programming drives long term potentiation and synaptic maturation. Neuroscience, Chicago, IL (Oct, 2019)

23. Han-A Park, Abigail U. Davis*, Allison Stumpf*, Jordan May*, Katheryn Broman*, and Kim Lackey.  Vitamin E promotes neurite outgrowth via Bcl-xL upregulation.  Neuroscience, Chicago, IL (Oct 20, 2019)

22. Allison Stumpf*, Katheryn Broman*, Katelyn E. Senkus*, Libo Tan, Kristi Crowe-White, and Han-A Park.  Lycopene Protects Cortical Neurons via Oxidative Stress-mediated ∆N-Bcl-xL formation. Nutrition, Baltimore, MD (Jun 10, 2019)

      Allison Stumpf* : Awarded with the Conference and Research Fund

      Link

21. Han-A Park, Nelli Mnatsakanyan, Katheryn Broman*, and Elizabeth A. Jonas. Vitamin E Prevents ΔN-Bcl-xL-associate Mitochondrial Dysfunction in Primary Hippocampal Neurons. Nutrition, Baltimore, MD (Jun 10, 2019) 

      Link

20. Nelli Mnatsakanyan, Han-A Park, Jing Wu, Marc C Llaguno, Besnik Murtishi, Maria Latta, Ellie Davis, Paige Miranda, Youshan Yang, Fred Sigworth, Elizabeth A Jonas.  Mitochondrial Megachannel Resides in Monomeric ATP synthase. 63rd Annual Meeting of the Biophysical Society, Baltimore, MD (Feb, 2019)

19. Nelli Mnatsakanyan, Han-A Park, Jing Wu, Besnik Murtishi, Paige Miranda, and Elizabeth A. Jonas. Excitotoxic cell death inducing megachannel within the ATP synthase: Mitochondrial permeability transition pore? Neuroscience, San Diego, CA (2018)

18. Pawel Licznerski, Han-A Park, Paige Miranda, Valentin Gribkoff, Rongmin Chen, Morven Graham, Richard Levy, and Elizabeth A. Jonas.Enhancement of mitochondrial efficiency causes synaptic metabolic maturation, reversing the abnormal protein translation in Fragile X syndrome. Neuroscience, San Diego, CA (2018)

17. Rongmin Chen, Han-A Park, Nelli Mnatsakanyan,Yulong Niu, Pawel Licznerski, Jing Wu, Paige Miranda, Morven Graham, Wim Mandmakers, Vincenzo Bonifati, Kambiz Alavian, and Elizabeth A. Jonas.  DJ1 deficiency disrupts mitochondrial inner membrane coupling to cause neuronal dysfunction in familial Parkinson’s disease. Neuroscience, San Diego, CA (2018)

16. Han-A Park, Nelli Mnatsakanyan, and Elizabeth A. Jonas. Neuroprotective properties of α-tocotrienol via regulation of oxidative stress-mediated ∆N-Bcl-xL formation. Nutrition, Boston, MA (2018)

15. Han-A Park and Elizabeth A. Jonas α-Tocotrienol protects primary hippocampal neurons against oxidative stress-mediated ΔN-Bcl-xL formation in the mitochondria. Experimental Biology, Chicago, IL (2017)

14. Han-A Park, Pawel Licznerski, Yulong Niu, Nelli Mnatsakanyan, Paige Miranda, Jing Wu, Silvio Sacchetti, Brian M. Polster, Kambiz N. Alavian, Elizabeth A. Jonas. Metabolic Control of Cell Death : The Role of Bcl-xL. Experimental Biology, San Diego, CA (2016)

Finalist at the ASN Emerging Leaders in Nutrition Science Poster Competition

 

13. Han-A Park, Pawel Licznerski, Paige Miranda, Yulong Niu, Silvio Sacchetti, Kambiz N. Alavian, and Elizabeth A. Jonas. Regulation of neuronal death and survival by interaction of pro and anti-death versions of Bcl-xL with the mitochondrial permeability transition pore, Neuroscience, Chicago, IL (2015)

 

12. Han-A Park, Pawel Licznerski, Yulong Niu, Kambiz N. Alavian, and Elizabeth A. Jonas. ABT-737 Inhibits Full Length And Cleaved Pro-Apoptotic Bcl-xL, Resulting in Differential Effects on Death And Survival. Experimental Biology, Boston, MA (2015)

Young Scientist Travel Award

 

11. Han-A Park, Pawel Licznerski, Kambiz N. Alavian, Marya Shanabrough, and Elizabeth A. Jonas. Inhibition of Bcl-xL arrests neurite outgrowth. Neuroscience, Washington, DC (2014)

 

10. Han-A Park, Kambiz N. Alavian, Silvio Sacchetti, and Elizabeth A. Jonas.  Dual role of Bcl-xL inhibitor ABT-737 in neuronal death and survival.  Neuroscience, San Diego, CA (2013)

9. Han-A Park, Natalia Kubicki, Surya Gnyawali, Yuk Cheung Chan, Sashwati Roy, Savita Khanna, and Chandan K. Sen. Natural vitamin E α-tocotrienol Protects against stroke by induction of multidrug resistance-associated protein 1. 4th annual Translational to Clinical (T2C) Wound Care Conference. Columbus. OH (2011)

Resident/Fellow Poster Award

 

8. Han-A Park, Natalia Kubicki, Surya Gnyawali, Yuk Cheung Chan, Sashwati Roy, Savita Khanna, and Chandan K. Sen. Natural vitamin E α-tocotrienol Protects against stroke by induction of multidrug resistance-associated protein 1. Dorothy M. Davis Heart and Lung Research Institute Research Day. Columbus. OH (2010)

 

7. Han-A Park, Savita Khanna, Cameron Rink, Surya Gnyawali, Natalia Kubicki, Sashwati Roy, and Chandan K. Sen. Glutathione disulfide as a cell death signal. 9th annual OSU Medical Center Research Day, Columbus, OH (2010)

Travel Award

 

6. Han-A Park, Savita Khanna, Cameron Rink, Surya Gnyawali, Natalia Kubicki, Sashwati Roy, and Chandan K. Sen. Glutathione disulfide as a cell death signal. Oxygen Club of California, Santa Barbara, CA (2010)

 

5. Han-A Park, Savita Khanna, Cameron Rink, Surya Gnyawali, Sashwati Roy, and Chandan K. Sen. Intracellular glutathione disulfide as neural cell death signal: regulation by alpha-tocotrienol. Neuroscience, Chicago, IL (2009)

 

4. Han-A Park, Savita Khanna, Cameron Rink, Surya Gnyawali, Sashwati Roy, and Chandan K. Sen. Glutathione disulfide induces neural cell death via 12-lipoxygenase pathway. 14th Annual Department of Surgery Research Conference. Columbus, OH (2009)

 

3. Han-A Park, Savita Khanna, Sashwati Roy, and Chandan K. Sen. GSSG: A Novel Cell Death Signal.  Russell Klein Memorial Nutrition Research Symposium, Columbus, OH (2008)

Basic Research Award

 

2. Han-A Park, Savita Khanna, Sashwati Roy, and Chandan K. Sen. GSSG: A Novel Cell Death Signal.  13th Annual Department of Surgery Research Conference, Columbus, OH (2008)

13th Annual Surgery Research Conference Award

 

1. Han-A Park, Savita Khanna, Sashwati Roy, and Chandan K. Sen. Does GSSG Signal for Cell Death?  6th annual OSU Medical Center Research Day, Columbus, OH (2007)

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