Journal Publications

On-going

* denotes UA students

Han-A Park, Allison Stumpf*, Katheryn Broman*, Kimberly H. Lackey, and Kristi M. Crowe-White. Differential Roles of Lycopene in Regulation of Oxidative Stress-mediated Mitochondrial Dysfunction in Primary Neurons

Free Radical Research

Submitted Jan 21 2020

 

Nelli Mnatsakanyan, Han-A Park, Jing Wu, Besnik Murtishi, Paige Miranda, and Elizabeth A. Jonas. ATP synthase c-subunit forms the largest mitochondrial inner membrane channel required for permeability transition.

PNAS.

Submitted Dec 2018

 

 

 

Published

 

* denotes UA students

15. Han-A Park, Nelli Mnatsakanyan, Katheryn Broman*, Abigail U. Davis*, Jordan May*, Pawel Licznerski, Kristi M. Crowe-White, Kimberly H. Lackey, and Elizabeth A. Jonas.  Alpha-Tocotrienol Prevents Oxidative Stress-Mediated Post-Translational Cleavage of Bcl-xL in Primary Hippocampal Neurons. International Journal of Molecular Sciences, (2019) 21(1), 220. doi: org/10.3390/ijms21010220.

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14. Rongmin Chen, Han-A Park, Nelli Mnatsakanyan, Yulong Niu, Pawel Licznerski, Jing Wu, Paige Miranda, Morven Graham, Jack Tang, Anita Boon, Giovanni Cossu, Wim Mandemakers, Vincenzo Bonifati, Peter Smith, Kambiz Alavian,  Vincenzo Bonifati, and Elizabeth A. Jonas. Parkinson’s Disease protein DJ-1 regulates ATP synthase protein components to increase neuronal process outgrowth. Cell Death & Disease, (2019) 13;10(6):469. doi: 10.1038/s41419-019-1679-x.

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13. Han-A Park, Katheryn Broman*, Allison Stumpf*, Sara Kazyak*, and Elizabeth A. Jonas. Nutritional Regulators of Bcl-xL in the Brain. Molecules, (2018) 19;23(11). pii: E3019. doi: 10.3390/molecules23113019. Review

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12. Han-A Park and Elizabeth A. Jonas. ΔN-Bcl-xL, a therapeutic target for neuroprotection. Neural Regeneration Research, (2017) 12(11):1791-1794. doi: 10.4103/1673-5374.219033. Review

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11. Han-A Park, Pawel Licznerski, Nelli Mnatsakanyan, Yulong Niu, Silvio Sacchetti, Jing Wu, Brian M. Polster, Kambiz N. Alavian, and Elizabeth A. Jonas.  Inhibition of Bcl-xL prevents pro-death actions of ΔN-Bcl-xL at the mitochondrial inner membrane during glutamate excitotoxicity. Cell Death & Differentiation, (2017) 24(11):1963-1974. doi: 10.1038/cdd.2017.123.

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10. Han-A Park, Pawel Licznerski, Kambiz N. Alavian, Marya Shanabrough, and Elizabeth A. Jonas. Bcl-xL is necessary for neurite outgrowth in hippocampal neurons. Antioxidants & Redox Signaling, (2015) 10;22(2):93-108. doi: 10.1089/ars.2013.5570.

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9. Hongmei Li, Han-A Park, and Elizabeth A. Jonas. Measurement of synaptic activity using fluorescent synaptopHluorin in isolated hippocampal neurons. Bio-Protocol, (2014)  5;4(23). pii: e1304.

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8. Han-A Park and Elizabeth A. Jonas. Mitochondrial membrane protein Bcl-xL, a regulator of adult neuronal growth and synaptic plasticity: multiple functions beyond apoptosis. Neural Regeneration Research, (2014) 1;9(19):1706-7. doi: 10.4103/1673-5374.143413. Review

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7. Kambiz N. Alavian, Gisela Beutner, Emma Lazrove, Silvio Sacchetti, Han-A Park, Pawel Licznerski, Hongmei Li, Panah Nabili, Kathryn Hockensmith, Morven Graham, George A. Porter, and Elizabeth A. Jonas. An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore. PNAS,  (2014) 22;111(29):10580-5. doi: 10.1073/pnas.1401591111.

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6. Elizabeth A. Jonas, Silvio Sacchetti, Han-A Park, Emma Lazrove, Gisela Beutner, George A. Porter, and Kambiz A. Alavian. The c-subunit of the ATP synthase forms the pore of the PTP. Biophysical Journal, 106, 3a-4a (2014)

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5. Han-A Park, Natalia Kubicki, Surya Gnyawali, Yuk Cheung Chen, Sashwati Roy, Savita Khanna, and Chandan K. Sen. Natural vitamin E α-tocotrienol protects against ischemic stroke by induction of multidrug resistance-associated protein 1. Stroke, (2011) 42(8):2308-14. doi: 10.1161/STROKEAHA.110.608547.

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4. Gayle Gordillo, Huiquing Fang, Han-A Park, and Sashwati Roy. Nox-4-dependent nuclear H2O2 drives DNA oxidation resulting in 8-OHdG as urinary biomarker and hemangioendothelioma formation.  Antioxidants & Redox Signaling, (2010) 15;12(8):933-43. doi: 10.1089/ars.2009.2917.

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3. Han-A Park, Savita Khanna, Cameron Rink, Surya Gnyawali, Sashwati Roy, and Chandan K. Sen. Glutathione disulfide induces neural cell death via a 12-lipoxygenase pathway. Cell Death & Differentiation, (2009) 16(8):1167-79. doi: 10.1038/cdd.2009.37.

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2. Savita Khanna, Han-A Park, Chandan K. Sen, Trimurtulu Golakoti, Krishanu Sengupta, Somepalli Venkateswarlu, and Sashwati Roy.  Neuroprotective and antiinflammatory properties of a novel demethylated curcuminoid. Antioxidants & Redox Signaling, (2009) 11(3):449-68. doi: 10.1089/ARS.2008.2230.

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1. Savita Khanna, Sashwati Roy, Han-A Park, and Chandan K. Sen. Regulation of c-Src activity in glutamate-induced neurodegeneration. Journal of Biological Chemistry, (2007) 10;282(32):23482-90.

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Book Chapters

4. Katheryn Broman*, Abigail U. Davis*, Jordan May*, and Han-A Park.  Neuroprotection - New Approaches and Prospects. Lifestyle factors, Mitochondrial Dynamics, and Neuroprotection. Intech. (2019)

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3. Han-A Park, and Elizabeth A. Jonas. Synaptic Plasticity. Chapter 3, Mitochondrial Regulators of Synaptic Plasticity in the Ischemic Brain. Intech. p39-67 (2017)

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2. Elizabeth A. Jonas, George A. Porter, Gisela Beutner, Nelli Mnatsakanyan, Han-A Park, Nikita Mehta, Rongmin Chen, Kambiz A. Alavian. Molecular Basis for Mitochondrial Signaling. Chapter 3, The mitochondrial permeability transition pore: molecular structure and function in health and disease. Springer. p69-105 (2017)

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1. Han-A Park, Sashwati Roy, Savita Khanna, and Chandan K. Sen. Method in Redox Signaling, Chapter 10, Current Technologies in Single Cell Microinjection and Application to Study Signal Transduction. Mary Ann Liebert, Inc. p71-77 (2010)

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Presentations

* denotes UA students

Pawel Licznerski, Han-A Park, Paige Miranda, Rongmin Chen, Morven Graham, Nelli Mnatsakanyan, Jing Wu, N. Cruz-Reyes, N. Mehta, S. Sohail, J. Salcedo,  Valentin Gribkoff, Besnik Murtishi, Harshvardhan Rolyan, Richard Levy, and Elizabeth A. Jonas. Mitochondrial inefficiency linked to abnormal metabolism, synaptic immaturity and behavioral deficits in fragile X syndrome. Neuroscience, Chicago (2019)

Nelli Mnatsakanyan, Han-A Park, Jing Wu, Marc C Llaguno, Besnik Murtishi, Paige Miranda, Fred Sigworth, Elizabeth A Jonas. Excitotoxic neuronal death inducing megachannel resides in monomeric F1FOATP synthase. Neuroscience, Chicago (2019)

Harshvardhan Rolyan, Paige Miranda, Han-A Park, Silvio Sacchetti, Kambiz Alavian,  Nelli Mnatsakanyan, Pawel Licznerski, H. Imamura, H. Noji, J. Shepherd, A. Chavez, Suzanne Zukin, and Elizabeth A Jonas. Mitochondria dependent metabolic programming drives long term potentiation and synaptic maturation. Neuroscience, Chicago (2019)

Jordan May*, Abigail U. Davis*, Allison Stumpf*, Katheryn Broman*, and Han-A Park.  Vitamin E promotes neurite outgrowth via Bcl-xL upregulation.  Neuroscience, Chicago (2019)

Allison Stumpf*, Katheryn Broman*, Katelyn E. Senkus*, Libo Tan, Kristi Crowe-White, and Han-A Park.  Lycopene Protects Cortical Neurons via Oxidative Stress-mediated ∆N-Bcl-xL formation. Nutrition, Baltimore (2019)

      Allison Stumpf* : Awarded with the Conference and Research Fund

Han-A Park, Nelli Mnatsakanyan, Katheryn Broman*, and Elizabeth A. Jonas. Vitamin E Prevents ΔN-Bcl-xL-associate Mitochondrial Dysfunction in Primary Hippocampal Neurons. Nutrition, Baltimore (2019)

Nelli Mnatsakanyan, Han-A Park, Jing Wu, Marc C Llaguno, Besnik Murtishi, Maria Latta, Ellie Davis, Paige Miranda, Youshan Yang, Fred Sigworth, Elizabeth A Jonas.  Mitochondrial Megachannel Resides in Monomeric ATP synthase. 63rd Annual Meeting of the Biophysical Society, Baltimore (2019)

Nelli Mnatsakanyan, Han-A Park, Jing Wu, Besnik Murtishi, Paige Miranda, and Elizabeth A. Jonas. Excitotoxic cell death inducing megachannel within the ATP synthase: Mitochondrial permeability transition pore? Neuroscience, San Diego (2018)

Pawel Licznerski, Han-A Park, Paige Miranda, Valentin Gribkoff, Rongmin Chen, Morven Graham, Richard Levy, and Elizabeth A. Jonas.

Enhancement of mitochondrial efficiency causes synaptic metabolic maturation, reversing the abnormal protein translation in Fragile X syndrome. Neuroscience, San Diego (2018)

Rongmin Chen, Han-A Park, Nelli Mnatsakanyan,Yulong Niu, Pawel Licznerski, Jing Wu, Paige Miranda, Morven Graham, Wim Mandmakers, Vincenzo Bonifati, Kambiz Alavian, and Elizabeth A. Jonas.  DJ1 deficiency disrupts mitochondrial inner membrane coupling to cause neuronal dysfunction in familial Parkinson’s disease. Neuroscience, San Diego (2018)

Han-A Park, Nelli Mnatsakanyan, and Elizabeth A. Jonas. Neuroprotective properties of α-tocotrienol via regulation of oxidative stress-mediated ∆N-Bcl-xL formation. Nutrition, Boston (2018)

Han-A Park and Elizabeth A. Jonas α-Tocotrienol protects primary hippocampal neurons against oxidative stress-mediated ΔN-Bcl-xL formation in the mitochondria. Experimental Biology, Chicago (2017)

Han-A Park, Pawel Licznerski, Yulong Niu, Nelli Mnatsakanyan, Paige Miranda, Jing Wu, Silvio Sacchetti, Brian M. Polster, Kambiz N. Alavian, Elizabeth A. Jonas. Metabolic Control of Cell Death : The Role of Bcl-xL. Experimental Biology, San Diego (2016)

Finalist at the ASN Emerging Leaders in Nutrition Science Poster Competition

 

Han-A Park, Pawel Licznerski, Paige Miranda, Yulong Niu, Silvio Sacchetti, Kambiz N. Alavian, and Elizabeth A. Jonas. Regulation of neuronal death and survival by interaction of pro and anti-death versions of Bcl-xL with the mitochondrial permeability transition pore, Neuroscience, Chicago (2015)

 

Han-A Park, Pawel Licznerski, Yulong Niu, Kambiz N. Alavian, and Elizabeth A. Jonas. ABT-737 Inhibits Full Length And Cleaved Pro-Apoptotic Bcl-xL, Resulting in Differential Effects on Death And Survival. Experimental Biology, Boston MA (2015)

Young Scientist Travel Award

 

Han-A Park, Pawel Licznerski, Kambiz N. Alavian, Marya Shanabrough, and Elizabeth A. Jonas. Inhibition of Bcl-xL arrests neurite outgrowth. Neuroscience, Washington DC (2014)

 

Han-A Park, Kambiz N. Alavian, Silvio Sacchetti, and Elizabeth A. Jonas.  Dual role of Bcl-xL inhibitor ABT-737 in neuronal death and survival.  Neuroscience, San Diego, CA (2013)

Han-A Park, Natalia Kubicki, Surya Gnyawali, Yuk Cheung Chan, Sashwati Roy, Savita Khanna, and Chandan K. Sen. Natural vitamin E α-tocotrienol Protects against stroke by induction of multidrug resistance-associated protein 1. 4th annual Translational to Clinical (T2C) Wound Care Conference. Columbus. OH (2011)

Resident/Fellow Poster Award

 

Han-A Park, Natalia Kubicki, Surya Gnyawali, Yuk Cheung Chan, Sashwati Roy, Savita Khanna, and Chandan K. Sen. Natural vitamin E α-tocotrienol Protects against stroke by induction of multidrug resistance-associated protein 1. Dorothy M. Davis Heart and Lung Research Institute Research Day. Columbus. OH. (2010)

 

Han-A Park, Savita Khanna, Cameron Rink, Surya Gnyawali, Natalia Kubicki, Sashwati Roy, and Chandan K. Sen. Glutathione disulfide as a cell death signal. 9th annual OSU Medical Center Research Day, Columbus, OH. (2010)

Travel Award

 

Han-A Park, Savita Khanna, Cameron Rink, Surya Gnyawali, Natalia Kubicki, Sashwati Roy, and Chandan K. Sen. Glutathione disulfide as a cell death signal. Oxygen Club of California, Santa Barbara, CA. (2010)

 

Han-A Park, Savita Khanna, Cameron Rink, Surya Gnyawali, Sashwati Roy, and Chandan K. Sen. Intracellular glutathione disulfide as neural cell death signal: regulation by alpha-tocotrienol. Neuroscience, Chicago, IL. (2009)

 

Han-A Park, Savita Khanna, Cameron Rink, Surya Gnyawali, Sashwati Roy, and Chandan K. Sen. Glutathione disulfide induces neural cell death via 12-lipoxygenase pathway. 14th Annual Department of Surgery Research Conference. Columbus, OH. (2009)

 

Han-A Park, Savita Khanna, Sashwati Roy, and Chandan K. Sen. GSSG: A Novel Cell Death Signal.  Russell Klein Memorial Nutrition Research Symposium, Columbus, OH. (2008)

Basic Research Award

 

Han-A Park, Savita Khanna, Sashwati Roy, and Chandan K. Sen. GSSG: A Novel Cell Death Signal.  13th Annual Department of Surgery Research Conference, Columbus, OH. (2008)

13th Annual Surgery Research Conference Award

 

Han-A Park, Savita Khanna, Sashwati Roy, and Chandan K. Sen. Does GSSG Signal for Cell Death?  6th annual OSU Medical Center Research Day, Columbus, OH. (2007)

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